Superbug – what antibiotics should be selected?


Scientists worry about a situation on the pharmaceutical market within the past 10-15 years. A lot of intensive antibiotics do not cope well with new bacterial infections. There are even examples in the medical practice when the antibiotics are completely ineffective during an infectious disease.

In 2017, the pharmaceutical field has been astonished by the news that a 70-year-old woman was diagnosed an infection caused by superbug Klebsiella pneumonia in the USA. The patient had sepsis and she died. Doctors could not save her because bacterium was resistant to 26 antibiotics. Even the most effective antibiotics such as Amoxicillin, Augmentin, Zithromax and Ciprofloxacin did not help to stop an infectious process.

Today the drugs from the group of fluoroquinolone and macrolides are the most effective antibiotics, but they are useless during the development of superbug. It is caused by two reasons:

  • Irrational and uncontrolled use of the antibiotics
  • Absence of a new approach to the development of the antibacterial products

Even such drugs as Zithromax and Ciprofloxacin (bacteria usually slowly develop resistance to them) do not always effectively reduce the activity of the pathogenic microflora.

Special antibiotics such as Colistin have been used in the treatment of superbug. The drug is not used in the everyday therapeutic practice, and therefore microorganisms are not resistant to it.

Farmers often use this drug. Colistin is added to food for pigs, and so animals do not get sick and grow better. Due to the use of the medication, bacteria have an opportunity to adjust to such antibiotic, and then a human is infected or this gene of the resistance may be given to other bacteria that are able to cause infection in people. It seems like some bacteria resistant to Colistin have appeared this way.

“Superbug will soon kill more people than cancer”

It is already known that era of the antibiotics will be short. Bacteria quickly adjust to the aggressive external action, and therefore they mutate every year. If scientists created newer products before, now the standard ways to get antibiotics are probably exhausted.

Now, scientists are looking methods to sole this situation. There are several successful chemical compounds to which none bacteria could produce a resistance in the laboratory conditions. But when these compounds turn into medications, it is unknown.

As there are no guarantees that a method to cope with resistance of superbug to the antibiotics may be found, WHO calls all people to reduce the use of the antibiotics, so that bacteria had less chance to adjust. There are even recommendations for people:

  • Take antibiotics only if they are prescribed by a doctor
  • Follow the recommendations for the use of the antibiotics even if you feel better
  • Do not terminate the treatment and do not start the use of the antibiotics again after several days of the break

If you started taking medications, you should completely neutralize the pathogenic microflora. Otherwise, it will develop and you will not have the required effect next time when you take the analogical drug.

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